Vitamin E attenuates the toxic effects of intrastriatal injection of 6-hydroxydopamine (6-OHDA) in rats: behavioral and biochemical evidence.
作者： Jean Lud Cadet , Mindy Katz , Vernice Jackson-Lewis , Stanley Fahn
DOI: 10.1016/0006-8993(89)91530-8
关键词:
摘要: Unilateral 6-hydroxydopamine (6-OHDA) injections into the striatum lead to development of apomorphine-induced rotation in rats. The circling behavior was associated with significant decreases dopamine, dihydroxyphenylacetic acid and homovanillic ipsilateral striatum. Pretreatments either D-alpha-tocopherol or all-racemic-alpha-tocopherol caused attenuation both behavioral biochemical abnormalities. These results are discussed terms their support for free radical hypothesis Parkinson's disease role antioxidants treatment this neurodegenerative disorder.
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