Differential contribution of NFATc2 and NFATc1 to TNF-alpha gene expression in T cells.
作者： Osamu Kaminuma , Fujiko Kitamura , Noriko Kitamura , Takachika Hiroi , Hiroyuki Miyoshi
DOI: 10.4049/JIMMUNOL.180.1.319
关键词:
摘要: The NFAT family transcription factors play crucial roles in immunological and other biological events; however, the functional differences among members have not been fully elucidated. This study investigated relative contribution of NFATc2 NFATc1 to transactivation cytokine genes T cells. Ectopic expression but NFATc1, especially its short isoform, enhanced TNF-alpha synthesis human cells at gene level, whereas both NFATs augmented IL-2 expression. In addition, a reduction shortest isoform using RNA interference technology failed suppress promoter/enhancer activity NFAT-binding site was up-regulated by associated similarly with this region. A mRNA NFATc2/NFATc1 chimeric molecules revealed that enhancing on lost truncation C-terminal domain. domain derived from behaved as dominant negative against promoter-dependent transcriptional We conclude is for
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