Compatibility and stability of binary mixtures of ketorolac tromethamine and tramadol hydrochloride injection concentrate and diluted infusion solution.

摘要: Objective Ketorolac added to tramadol as an injection mixture convenient for clinical use has been shown be effective balanced analgesic regimen in alleviating moderate-to-severe pain. However, analytical confirmation of the compatibility and stability this combination is not available. This study examined combination. Methods Two different mixtures containing ketorolac tromethamine hydrochloride were examined: (10 mg/mL) (33.3 prepared concentrate ampoule mingled together ratio one ampoule; diluted (2 (20 saline infusion solution, with or without pH adjustment. The visually inspected precipitation color change. Quantitative chemical analysis was performed on days 0, 1, 3 7 by high-performance liquid chromatography. Results When stored at room temperature under ambient light, mg/mL)-tramadol adjustment adjusted 5–8, physico-chemically stable, neither visible nor loss concentration found. With solution 9, however, occurred immediately, resulting a significant tramadol. Conclusion suggests that ready-to-use ketorolac-tramadol mixture, either undiluted physiological can prepared, shelf life least when light.