Protein conformational disorder and enzyme catalysis.
作者： Cindy Schulenburg , Donald Hilvert
DOI: 10.1007/128_2012_411
关键词:
摘要: Though lacking a well-defined three-dimensional structure, intrinsically unstructured proteins are ubiquitous in nature. These molecules play crucial roles many cellular processes, especially signaling and regulation. Surprisingly, even enzyme catalysis can tolerate substantial disorder. This observation contravenes conventional wisdom but is relevant to an understanding of how protein dynamics modulates function. chapter reviews properties characteristics disordered proteins, emphasizing examples enzymes that lack defined structures, considers implications structural disorder for catalytic efficiency evolution.
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