Role of surgery in the treatment of intrahepatic cholangiocarcinoma.

摘要: Intrahepatic Cholangiocarcinoma (ICC) is the second most common primary liver cancer, accounting for 10% to 15% of hepatic malignancy, and its incidence increasing in Western Countries. Surgery with curative intent only treatment that offers a chance long-term survival, reported 5-year overall survival rate ranging from 17% 48%. In recent series postoperative mortality lower than 5% morbidity varied 6% 66%. The macroscopic classification ICC, proposed by Liver Cancer Study Group Japan (LCSGJ), reflects different biologic behaviours, pattern tumor growth clinicopathological findings. important prognostic factors after resection are positive margins, lymph-node metastases, size, presence macrovascular invasion intrahepatic metastases. Unfortunately, recurrence still frequent it leading cause death. according location extension disease. Recently, expression several genes found be related carcinogenesis ICC. These molecular findings helpful differentiate biological behaviour will provide evidence development new target therapies.