Nonsteroidal anti-inflammatory drugs and risk of lung cancer.

摘要: Regular aspirin and non-aspirin nonsteroidal anti-inflammatory drug (NSAID) use is associated with a reduced risk of colorectal cancer. The effect NSAIDs on the other cancers remains unclear. To evaluate whether or specific protects against lung cancer, we conducted case-control study nested in cohort subjects 40-84 years old 1995-2004, without diagnosis cancer before start date, at least 2 enrollment general practitioner providing data to Health Improvement Network (THIN) database UK. Patients who had first primary during period were considered cases. A random sample 10,000 controls was frequency-matched cases for age, sex calendar year. index date exposure definition 1 year within controls. Relative risks 95% confidence intervals estimated using conditional logistic regression stratified matching factors. Factors such as smoking, chronic obstructive pulmonary disease, cardiovascular diseases body mass introduced model. We identified 4,336 incident (incidence rate 7.6 per person-years). Compared no prescription NSAID prior 0.76 (0.61-0.94) among those received previous treatment duration corresponding relative 1.15 (0.99-1.34) aspirin. In conclusion, might be slightly Aspirin not reduction, perhaps due residual confounding.