In Vitro “Wound” Healing: Experimentally Based Phenomenological Modeling
作者： Fred J. Vermolen , Amit Gefen , John W. C. Dunlop
关键词:
摘要: We discuss the applicability of some elementary models for closure in vitro “wounds” that are inflicted monolayer cell cultures (also termed “wound healing assays”). These can be applied to simulation superficial wounds as long they only concern epidermis. test several based on a curvature driven displacement, simple partial differential equation model which actual cellular density is tracked. Finally, semi-stochastic evaluated.
mpg.de
core.ac.uk
sci-hub.se 参考文章(19)
Leila Cuttle, Margit Kempf, Gael E. Phillips, Julie Mill, Mark T. Hayes, John F. Fraser, Xue-Qing Wang, Roy M. Kimble, A porcine deep dermal partial thickness burn model with hypertrophic scarring Burns. ,vol. 32, pp. 806- 820 ,(2006) , 10.1016/J.BURNS.2006.02.023
J.A. Adam, A simplified model of wound healing (with particular reference to the critical size defect) Mathematical and Computer Modelling. ,vol. 30, pp. 23- 32 ,(1999) , 10.1016/S0895-7177(99)00145-4
F. J. Vermolen, A. Gefen, A semi-stochastic cell-based formalism to model the dynamics of migration of cells in colonies Biomechanics and Modeling in Mechanobiology. ,vol. 11, pp. 183- 195 ,(2012) , 10.1007/S10237-011-0302-6
E. Javierre, P. Moreo, M. Doblaré, J.M. García-Aznar, Numerical modeling of a mechano-chemical theory for wound contraction analysis International Journal of Solids and Structures. ,vol. 46, pp. 3597- 3606 ,(2009) , 10.1016/J.IJSOLSTR.2009.06.010
Hiroshi Ohno, Yasuhiro Naito, Hiromu Nakajima, Masaru Tomita, Construction of a biological tissue model based on a single-cell model: A computer simulation of metabolic heterogeneity in the liver lobule Artificial Life. ,vol. 14, pp. 3- 28 ,(2008) , 10.1162/ARTL.2008.14.1.3
François Graner, James A. Glazier, Simulation of biological cell sorting using a two-dimensional extended Potts model Physical Review Letters. ,vol. 69, pp. 2013- 2016 ,(1992) , 10.1103/PHYSREVLETT.69.2013
Sophia Maggelakis, Modeling the role of angiogenesis in epidermal wound healing Discrete and Continuous Dynamical Systems-series B. ,vol. 4, pp. 267- 273 ,(2003) , 10.3934/DCDSB.2004.4.267
Xue-Qing Wang, Pei-Yun Liu, Margit Kempf, Leila Cuttle, Allen Hong-En Chang, Michael Wong, Olena Kravchuk, Julie Mill, Roy M. Kimble, Burn healing is dependent on burn site: a quantitative analysis from a porcine burn model. Burns. ,vol. 35, pp. 264- 269 ,(2009) , 10.1016/J.BURNS.2008.05.030
F.J. Vermolen, E. Javierre, Computer simulations from a finite-element model for wound contraction and closure. Journal of Tissue Viability. ,vol. 19, pp. 43- 53 ,(2010) , 10.1016/J.JTV.2009.11.003
E.A. Gaffney, K. Pugh, P.K. Maini, F. Arnold, Investigating a simple model of cutaneous wound healing angiogenesis. Journal of Mathematical Biology. ,vol. 45, pp. 337- 374 ,(2002) , 10.1007/S002850200161