Resolvins: Natural Agonists for Resolution of Pulmonary Inflammation

摘要: Inappropriate or excessive pulmonary inflammation can contribute to chronic lung diseases. In health, the resolution of is an active process that terminates inflammatory responses. The recent identification endogenous lipid-derived mediators has provided a window explore pathobiology disease and structural templates for design novel pro-resolving therapeutics. Resolvins (resolution-phase interaction products) are family enzymatically generated from essential omega-3 polyunsaturated fatty acids. Two molecular series resolvins have been characterised, namely E- D-series which possess distinct structural, biochemical pharmacological properties. Acting as agonists at specific receptors (CMKLR1, BLT1, ALX/FPR2 GPR32), signal potent counter-regulatory effects on leukocyte functions, including preventing uncontrolled neutrophil swarming, decreasing generation cytokines, chemokines reactive oxygen species promoting clearance apoptotic neutrophils inflamed tissues. Hence, provide mechanisms cytoprotection host tissues potentially detrimental unresolved inflammation. This review highlights experimental findings in resolvin research, impact these stereospecific molecules tissue catabasis.