The role of developmental neurotoxicology studies in risk assessment.

作者: Hugh A. Tilson

DOI: 10.1177/019262330002800119

关键词:

摘要: A number of questions have been raised about the use US Environmental Protection Agency's Developmental Neurotoxicity Testing Guideline (DNTG) in hazard identification chemicals. The applicability and sensitivity animal tests DNTG relative to human developmental neurotoxicity recently questioned. In a workshop held 1989, participants compared effects several known neurotoxicants humans models concluded that would detected neurotoxicants. They also although procedural differences may differ testing animals, neurobiologic functions (ie, autonomic, sensory, motor, cognitive) affected by chemical exposure were similar. cases where has with other measures reproductive toxicity, relatively sensitive specific. To date, DNTGs required 12 times, for 9 pesticides 3 solvents. T...

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