Tau-binding antibodies
作者： Georges Mairet-Coello , Patrick Downey , David James Mcmillan , Jean-Philippe Courade , David Edward Ormonde Knight
DOI:
关键词:
摘要: The invention relates to isolated Tau-binding antibodies or binding fragments thereof. also nucleic acid molecules encoding the light and/or heavy chain of said antibodies, a cloning expression vector, host cell producing method and Furthermore, use thereof as therapeutically active agent in treating tauopathy, wherein tauopathy is Alzheimer's disease progressive supranuclear palsy, diagnostic diagnosing tauopathy.
google.co.jp参考文章(77)
C. Chen, V.A. Roberts, S. Stevens, M. Brown, M.P. Stenzel-Poore, M.B. Rittenberg, Enhancement and destruction of antibody function by somatic mutation: unequal occurrence is controlled by V gene combinatorial associations. The EMBO Journal. ,vol. 14, pp. 2784- 2794 ,(1995) , 10.1002/J.1460-2075.1995.TB07278.X
Guo-Liang Yu, Weimin Zhu, Yaohuang Ke, Anti-vegf antibody ,(2008)
Andre Van De Voorde, Eugeen Vanmechelen, Monoclonal antibodies specific for an epitope of phosphorylated tau, and their use ,(1995)
Michel Demeule, Jean-Paul Castaigne, Dominique Boivin, Christian Che, Betty Lawrence, Leptin and leptin analog conjugates and uses thereof ,(2009)
Marc Vandermeeren, Andre Van De Voorde, Eugeen Vanmechelen, Monoclonal antibodies specific for phf-tau, hybridomas secreting them, antigen recognition by these antibodies and their applications ,(1994)
De Voorde Andre Van, Marc Vandermeeren, Marc Mercken, Eva-Maria Mandelkow, Eugeen Vanmechelen, Monoclonal Antibodies Directed Against The Microtubule-Associated Protein Tau ,(1992)
George Joseph Smith, Jeff Xianchao Zhu, Kenneth Nelson Wills, Antigenic tau peptides and uses thereof ,(2010)
Michel Demeule, Jean-Paul Castaigne, Christian Che, Anthony Regina, Compositions and methods for the transport of therapeutic agents ,(2010)
Alfonso R. Gennaro, Joseph P. Remington, Remington's pharmaceutical sciences Published in <b>1975</b> in Easton Pa) by Mack. ,(1985)
Catherine Gagnon, Carine Thiot, Christian Che, Michel Demeule, Jean-Paul Castaigne, Conjugates of neurotensin or neurotensin analogs and uses thereof ,(2009)