Comparison of Rift Valley fever virus replication in North American livestock and wildlife cell lines.

摘要: Rift Valley fever virus (RVFV) causes disease outbreaks across Africa and the Arabian Peninsula, resulting in high morbidity mortality among young domestic livestock, frequent abortions pregnant animals, potentially severe or fatal humans. The possibility of RVFV spreading to US other countries worldwide is significant concern animal public health, livestock production trade. mechanism for persistence during inter-epidemic periods may be through mosquito transovarial transmission and/or by means a wildlife reservoir. Field investigations endemic areas previous vivo studies have demonstrated that can infect wide range including indigenous wild ruminants Africa. Yet no predominant reservoir has been identified, gaps our knowledge permissive hosts still remain. In North America, goats, sheep cattle are susceptible several competent vectors exist. Wild such as deer might serve given their abundance, distribution, overlap with farms human populated could represent an important risk factor. objective this study was assess variety cell lines derived from American susceptibility permissiveness RVFV. Results suggest replicate native species white-tailed deer, possibly non-ruminant animals. This work serves guide support future model assessment regarding high-consequence zoonotic pathogen.