Neonatal cholestasis in congenital pituitary hormone deficiency and isolated hypocortisolism: characterization of liver dysfunction and follow-up.
作者： Débora Braslavsky , Ana Keselman , Marcela Galoppo , Carol Lezama , Ana Chiesa
DOI: 10.1590/S0004-27302011000800017
关键词:
摘要: INTRODUCTION: Neonatal cholestasis due to endocrine diseases is infrequent and poorly reco-gnized. Referral the pediatric endocrinologist delayed. OBJECTIVE: We characterized in infants with congenital pituitary hormone deficiencies (CPHD), its resolution after replacement therapy (HRT). SUBJECTS AND METHODS: Sixteen patients (12 males) were included; eleven CPHD, five isolated central hypocortisolism. RESULTS: Onset of occurred at a median age 18 days life (range 2-120). Ten nine had elevated transaminases γGT, respectively. 32 1 - 72). Remission 65 days, whereas liver enzymes 90 days. In our cohort isolated, hypocortisolism was transient disorder. CONCLUSION: Cholestasis hormonal completely resolved upon introduction HRT. Isolated may be cause that needs re-evaluated remission cholestasis.
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