Two K+ channel types, muscarinic agonist-activated and inwardly rectifying, in a Cl- secretory epithelium: the avian salt gland.

摘要: Patches of membrane on cells isolated from the nasal salt gland domestic duck typically contained two types K+ channel. One was a large-conductance ("maxi") channel which activated by intracellular calcium and/or depolarizing voltages, and other smaller-conductance exhibited at least conductance levels displayed pronounced inward rectification. Barium blocked both channels, but tetraethylammonium chloride quinidine selectively larger The large did not appear to open under resting conditions could be application muscarinic agonist, carbachol. smaller channels were gating affected Both these reside in basolateral membranes Cl- secretory they play different roles life cell.