Molecular marks for epigenetic identification of developmental and cancer stem cells.

摘要: Epigenetic regulations of genes by reversible methylation DNA (at the carbon-5 cytosine) and numerous modifications histones play important roles in normal physiology development, epigenetic deregulations are associated with developmental disorders various disease states, including cancer. Stem cells have capacity to self-renew indefinitely. Similar stem cells, some malignant divide indefinitely referred as cancer cells. In recent times, direct correlation between reprogramming cell is emerging. Major discoveries were made investigations on gene products, also known master regulators totipotency inducer pluoripotency, namely, OCT4, NANOG, cMYC, SOX2, Klf4, LIN28. The challenge induce pluripotency insertion four (Oct4, Sox2, c-Myc) into genome. There always risks silencing these host particularly, when introduced through retroviral techniques. this contribution, we will discuss major within chromatin progression comparison development cell. These may be considered molecular signatures for predicting identifying states.