Vascular endothelial growth factor (VEGF)-induced retinal vascular permeability is mediated by intercellular adhesion molecule-1 (ICAM-1).
作者： Kazuaki Miyamoto , Samer Khosrof , Sven-Erik Bursell , Yasufumi Moromizato , Lloyd Paul Aiello
DOI: 10.1016/S0002-9440(10)65044-4
关键词:
摘要: Two prominent vascular endothelial growth factor (VEGF)-induced retinal effects are permeability and capillary nonperfusion. The mechanisms by which these occur not completely known. Using a rat model, we show that intravitreous injections of VEGF precipitate an extensive leukocyte stasis (leukostasis) coincides with enhanced leukostasis is accompanied the up-regulation intercellular adhesion molecule-1 expression in retina. inhibition bioactivity neutralizing antibody prevents increases 79% 54%, respectively. These data first to demonstrate nonendothelial cell type contributes VEGF-induced permeability. Additionally, they identify potential mechanism for
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