Severe vitamin D deficiency is associated with non‐tuberculous mycobacterial lung disease: A case‐control study

摘要: Background and objective Previous studies have found evidence of an association between tuberculosis vitamin D deficiency (VDD). However, the VDD infection caused by non-tuberculous mycobacteria (NTM) has never been studied. This study evaluated prevalence severity in NTM lung disease attempted to identify predictive factors. Methods Age- sex-matched case-control was conducted assess patients with disease. Results After adjusting for potential confounding factors, adjusted mean serum level 25-hydroxyvitamin (25(OH)D) levels lower 104 (10.7 ng/mL, 95% confidence interval (CI) 4.5–16.8 ng/mL) than that 312 controls (13.7 ng/mL, CI 7.4–19.5 ng/mL) (P = 0.012). Although defined as 25(OH)D <20 ng/mL not different, severe <10 ng/mL more prevalent (P < 0.001). In multivariate analysis, (but mild) independently associated (adjusted odds ratio 3.9, 1.9–8.5, P < 0.001). Conclusions Patients a high disease. Further are needed examine causality.