Mammalian target of rapamycin signaling is involved in the vasculogenic mimicry of glioma via hypoxia-inducible factor-1α
作者： MIN HUANG , YIQUAN KE , XINLIN SUN , LI YU , ZHILIN YANG
DOI: 10.3892/OR.2014.3454
关键词:
摘要: Abstract The mammalian target of rapamycin (mTOR) is a crucial regulator in malignant gliomas. Vasculogenic mimicry (VM) describes functional channels established by highly tumor cells that different from endothelium-lined blood vessels. Our previous studies confirmed the existence and clinical significance VM medulloblastoma glioblastoma. In present study, immunohistochemical CD34/PAS histochemical double-staining, 34 cases (26.8%) with structures were identified among total 127 glioma cases, these associated mTOR expression specimens. In vitro, U87 glioblastoma formed tube similar to HUVECs on Matrigel 3D culture, mTOR-specific inhibitor rapamycin inhibited formation under both normoxia hypoxia. addition, siRNA molecules signaling cascade formation, particularly HIF-1α. Taken together, our results demonstrated involved may be potential therapeutic for
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