Citrus Flavonoids as Promising Phytochemicals Targeting Diabetes and Related Complications: A Systematic Review of In Vitro and In Vivo Studies.

摘要: The consumption of plant-based food is important for health promotion, especially concerning the prevention and management chronic diseases. Flavonoids are main bioactive compounds in citrus fruits, with multiple beneficial effects, antidiabetic effects. We systematically review potential action molecular mechanisms flavonoids based on vitro vivo studies. A search PubMed, EMBASE, Scopus, Web Science Core Collection databases articles published since 2010 was carried out using keywords citrus, flavonoid, diabetes. All identified were analyzed, data extracted a standardized form. 38 articles, which reported that 19 flavonoids, including 8-prenylnaringenin, cosmosiin, didymin, diosmin, hesperetin, hesperidin, isosiennsetin, naringenin, naringin, neohesperidin, nobiletin, poncirin, quercetin, rhoifolin, rutin, sineesytin, sudachitin, tangeretin, xanthohumol, have potential. These regulated biomarkers glycemic control, lipid profiles, renal function, hepatic enzymes, antioxidant modulated signaling pathways related to glucose uptake insulin sensitivity involved pathogenesis diabetes its complications. Citrus therefore, promising candidates, while their effects remain be verified forthcoming human