Human Phaeohyphomycotic Osteomyelitis Caused by the Coelomycete Phomopsis Saccardo 1905: Criteria for Identification, Case History, and Therapy

摘要: The Sphaeropsidales, coelomycetous fungi producing asexual conidia within enclosed conidiomata (pycnidia), are saprobic on numerous vascular plants. Despite their ubiquitous nature, only a limited number of genera have been documented as causing human disease. We report what we believe to be the first case osteomyelitis due Phomopsis species in chronically immunosuppressed female. patient developed subcutaneous abscess distal phalanx right fourth finger complicated by osteomyelitis. Operative specimens revealed fungal hyphae and pure culture mould. was treated with 6-month course itraconazole. At 16 months follow-up, she remained free recurrence. differ from similar, more frequently reported Phoma having immersed, thick-walled, multiloculate production alpha (short, ellipsoidal) beta (long, filamentous) conidia.