Antibiotics acting as neuroprotectants via mechanisms independent of their anti-infective activities
作者： Matthew L. Stock , Kara J. Fiedler , Sreemoyee Acharya , Jennifer K. Lange , Gregory S.A. Mlynarczyk
DOI: 10.1016/J.NEUROPHARM.2013.04.059
关键词:
摘要: This review considers available evidence that some antibiotics have ancillary neuroprotective effects. Notably, β-lactam are believed to increase the expression of glutamate transporter GLT1, potentially relieving neurological excitotoxicity characterizes disorders like amyotrophic lateral sclerosis. Minocycline has shown promise in reducing severity a number diseases, including multiple sclerosis, most likely by apoptosis and inflammatory mediators brain. Rapamycin inhibits activity serine/threonine protein kinase role pathogenesis numerous neurologic diseases. Herein we examine unique aspects these drugs originally developed as anti-infective agents.
sci-hub.se 参考文章(152)
Baylas H, Atilla G, Effect of various demineralizing agents on mineral contents of cementum surfaces (an electron probe analysis). Journal of Marmara University Dental Faculty. ,vol. 2, pp. 515- ,(1996)
A pilot clinical trial of creatine and minocycline in early Parkinson disease: 18-month results. Clinical Neuropharmacology. ,vol. 31, pp. 141- 150 ,(2008) , 10.1097/WNF.0B013E3181342F32
J Hugon, J M Vallat, M Dumas, Role of glutamate and excitotoxicity in neurologic diseases Revue Neurologique. ,vol. 152, pp. 239- 248 ,(1996)
Minghua Chen, Victor O. Ona, Mingwei Li, Robert J. Ferrante, Klaus B. Fink, Shan Zhu, Jie Bian, Lei Guo, Laurie A. Farrell, Steve M. Hersch, Wendy Hobbs, Jean-Paul Vonsattel, Jang-Ho J. Cha, Robert M. Friedlander, Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease Nature Medicine. ,vol. 6, pp. 797- 801 ,(2000) , 10.1038/77528
Dexiang Chen, Ryan L. Endres, Cherie A. Erickson, Kathleen F. Weis, Martha W. McGregor, Yoshihiro Kawaoka, Lendon G. Payne, Epidermal immunization by a needle-free powder delivery technology: immunogenicity of influenza vaccine and protection in mice. Nature Medicine. ,vol. 6, pp. 1187- 1190 ,(2000) , 10.1038/80538
P. Periti, Immunopharmacology of Oral Betalactams Journal of Chemotherapy. ,vol. 10, pp. 91- 96 ,(1998) , 10.1179/JOC.1998.10.2.91
Aristea S. Galanopoulou, Jan A. Gorter, Carlos Cepeda, Finding a better drug for epilepsy: The mTOR pathway as an antiepileptogenic target Epilepsia. ,vol. 53, pp. 1119- 1130 ,(2012) , 10.1111/J.1528-1167.2012.03506.X
Mukundan G. Attur, Steven B. Abramson, Mandar N. Dave, Steven A. Stuchin, Indravadan V. Patel, Rajesh N. Patel, Ashok R. Amin, A Novel Mechanism of Action of Chemically Modified Tetracyclines: Inhibition of COX-2-Mediated Prostaglandin E2 Production Journal of Immunology. ,vol. 163, pp. 3459- 3467 ,(1999)
RACHEL A. GORDON, RANA MAYS, BRITTANY SAMBRANO, TIFFANY MAYO, WHITNEY LAPOLLA, Antibiotics used in nonbacterial dermatologic conditions. Dermatologic Therapy. ,vol. 25, pp. 38- 54 ,(2012) , 10.1111/J.1529-8019.2012.01496.X
Khalid Hamawi, Ahmed H. Al-Jedai, Syed M. Raza, Hakeam A. Hakeam, Sirolimus induced dyslipidemia in tacrolimus based vs. tacrolimus free immunosuppressive regimens in renal transplant recipients. Annals of Transplantation. ,vol. 13, pp. 46- 53 ,(2008)