Sustained expansion of NKT cells and antigen-specific T cells after injection of α-galactosyl-ceramide loaded mature dendritic cells in cancer patients
作者： David H. Chang , Keren Osman , John Connolly , Anjli Kukreja , Joseph Krasovsky
DOI: 10.1084/JEM.20042592
关键词:
摘要: Natural killer T (NKT) cells are distinct glycolipid reactive innate lymphocytes that implicated in the resistance to pathogens and tumors. Earlier attempts mobilize NKT cells, specifically, vivo humans met with limited success. Here, we evaluated intravenous injection of monocyte-derived mature DCs were loaded a synthetic cell ligand, α-galactosyl-ceramide (α-GalCer; KRN-7000) five patients who had advanced cancer. Injection α-GalCer–pulsed, but not unpulsed, dendritic (DCs) led >100-fold expansion several subsets all patients; these could be detected for up 6 mo after vaccination. activation was associated an increase serum levels interleukin-12 p40 IFN-γ inducible protein-10. In addition, there memory CD8+ specific cytomegalovirus response α-GalCer–loaded DCs, unpulsed DCs. These data demonstrate feasibility sustained humans, including have cancer, suggest might help boost adaptive immunity vivo.
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