Deletion of the MAD2L1 spindle assembly checkpoint gene is tolerated in mouse models of acute T-cell lymphoma and hepatocellular carcinoma

摘要: An estimated 350 billion of the cells in human body are dividing at any given moment. Every cell division requires 46 chromosomes cell, which store genetic information that needs to survive, be copied and distributed evenly between two new cells. Sometimes mistakes can result have wrong number – a state called aneuploidy. Aneuploidy is rare healthy but occurs over 75% cancers. It process chromosomal instability often leads death However, it not well understood how aneuploidy affects cancer develop or behave. Mice commonly used investigate because they many similarities with humans. To better understand relationship cancer, Foijer, Albacker et al. engineered mice could induce liver immune T-cells. This modification accelerated formation lymphoma system. The these cancers varied greatly, demonstrating experience constant instability. Overall, this suggests increases likelihood developing. mouse closely resemble their counterparts, so potentially test drugs. In future, developing therapies selectively target aneuploid treatments fewer side effects than existing treatments.