Myalgic Encephalomyelitis/Chronic Fatigue Syndrome in the Era of the Human Microbiome: Persistent Pathogens Drive Chronic Symptoms by Interfering With Host Metabolism, Gene Expression, and Immunity

摘要: The illness ME/CFS has been repeatedly tied to infectious agents such as Epstein Barr Virus. Expanding research on the human microbiome now allows ME/CFS-associated pathogens be studied interacting members of communities. Humans harbor these vast ecosystems bacteria, viruses and fungi in nearly all tissue blood. Most well-studied inflammatory conditions are dysbiosis or imbalance microbiome. While gut identified ME/CFS, microbes outside can also contribute illness. Pathobionts, their associated proteins/metabolites, often control metabolism gene expression a manner that pushes body toward state Intracellular pathogens, including many with drive by directly interfering transcription, translation, DNA repair processes. Molecular mimicry between host pathogen proteins/metabolites further complicates this interference. Other disable mitochondria dysregulate nervous system signaling. Antibodies and/or clonal T cells patients likely activated response persistent pathogens. Different have evolved similar survival mechanisms immune metabolic pathways. dysfunction driven organisms result clusters symptoms. may pathogen-induced dysfunction, nature symptom presentation varying based patient's unique environmental history. Under conditions, would benefit from treatments support an effort reverse disease process.