Role of cardiac myocyte tissue factor in heart hemostasis

摘要: Summary. Background: The tissue-specific pattern of tissue factor (TF) expression suggests that it plays a major role in the hemostatic protection specific organs, such as heart and lung. In support this notion, we found mice expressing very low levels TF exhibit defects Hemosiderosis fibrosis are observed hearts all early 3 months age. contrast, +/– 50% wild-type had no detectable defects. Objective methods: objective study was to determine threshold is required maintain hemostasis under normal pathologic conditions, investigate cardiac myocyte using with altered myocytes. Results: First, 20% activity their hemosiderosis by 6 Secondly, selective deletion gene myocytes mild defect conditions but exhibited significant increase after challenge isoproterenol. Finally, showed myocyte-specific overexpression abolished hemosiderin deposition mice. Conclusions: Taken together, our results indicate important conditions.