Thyroxine transport proteins of plasma. Molecular properties and biosynthesis.

摘要: Publisher Summary This chapter discusses the molecular properties and biosynthesis of thyroxine transport proteins plasma. The purification complete amino acid sequence high-resolution X-ray diffraction model pre-albumin (PA) have helped enhance knowledge physiology these proteins. Apart from thyroxine-binding globulin PA, several other serum interact with thyroid hormones. However, both human bovine albumin, in addition to less active sites, possess one binding site for a rather high affinity constant. Despite its abundance plasma, albumin transports only about 10% circulating hormone. Other interacting include lipoproteins. In severe illnesses acute stress, disappearance rate PA plasma is usually normal, which suggests that low level patients result synthesis.