Oncoprotein (c-myc, c-erbB1, c-erbB2, c-fos) and suppressor gene product (p53) expression in squamous cell carcinomas of the lung. Clinical and biological correlations.

摘要: The expression of the protooncogene encoded proteins (c-erbB1, c-erb B2, c-myc, c-fos) and suppressor gene product p53 was analyzed in 81 human squamous cell carcinomas lung correlated with clinical parameters patients (patient survival, presence metastases tumor stage) biological characteristics tumors (tumor growth nude mice, DNA-ploidy, proliferative activity, drug-resistance P-glycoprotein or gluathione S-transferase expression). By means immunohistochemistry, c-erbB1 oncoprotein (EGF-receptor) detected 79% tumors, c-erbB2 (c-neu) 35%, c-myc 48%, c-fos 41%, 43% tumors. Patients positive had a poor prognosis (p = 0.021). In addition, these were more frequently drug resistant 0.0067). A significant correlation between mice demonstrated 0.017). Therefore, EGF-receptor products may serve as prognostic factors for aggressiveness response to chemotherapy. No found stage, metastasis DNA-ploidy. contrast results, no relationship c-neu any examined. Aneuploid expressed than diploid 0.027). However, there difference survival patients, metastasis, activity