Interleukin-13 reduces cardiac injury and prevents heart dysfunction in viral myocarditis via enhanced M2 macrophage polarization
作者： Honghui Yang , Yan Chen , Chuanyu Gao
DOI: 10.18632/ONCOTARGET.20111
关键词:
摘要: Viral myocarditis is one of the major causes congestive heart failure and dilated cardiomyopathy. Recent reports have demonstrated an essential role cytokines, like interleukin-13 (IL-13), in pathogenesis viral myocarditis, while underlying mechanisms remain poorly defined. Here, using a coxsackie virus B3 (CVB3)-infection model BALB/C mice, we showed that IL-13 protected mouse function seemingly through reduction T lymphocyte immunity induction M2 macrophage polarization. Adoptive transfer to macrophages mimicked effects on protection from suggesting may be primarily regulation Together, our data suggest application treatment reduce cardiac Injury protect via enhanced
sci-hub.st 参考文章(37)
Massimo Locati, Alberto Mantovani, Antonio Sica, Macrophage Activation and Polarization as an Adaptive Component of Innate Immunity Development and Function of Myeloid Subsets. ,vol. 120, pp. 163- 184 ,(2013) , 10.1016/B978-0-12-417028-5.00006-5
Yunwei Lou, Suxia Liu, Cheng Zhang, Guizhong Zhang, Jingjing Li, Mei Ni, Guipeng An, Mei Dong, Xiaoling Liu, Faliang Zhu, Wenqian Zhang, Fei Gao, Youhai H. Chen, Yun Zhang, Enhanced atherosclerosis in TIPE2-deficient mice is associated with increased macrophage responses to oxidized low-density lipoprotein Journal of Immunology. ,vol. 191, pp. 4849- 4857 ,(2013) , 10.4049/JIMMUNOL.1300053
Juan M. Spera, Claudia K. Herrmann, Mara S. Roset, Diego J. Comerci, Juan E. Ugalde, A Brucella Virulence Factor Targets Macrophages to Trigger B-cell Proliferation Journal of Biological Chemistry. ,vol. 288, pp. 20208- 20216 ,(2013) , 10.1074/JBC.M113.453282
Xiaohai Wang, Wen-Jye Lin, Kouji Izumi, Qi Jiang, Kuo-Pao Lai, Defeng Xu, Lei-Ya Fang, Tianjing Lu, Lei Li, Shujie Xia, Chawnshang Chang, Increased Infiltrated Macrophages in Benign Prostatic Hyperplasia (BPH) ROLE OF STROMAL ANDROGEN RECEPTOR IN MACROPHAGE-INDUCED PROSTATE STROMAL CELL PROLIFERATION Journal of Biological Chemistry. ,vol. 287, pp. 18376- 18385 ,(2012) , 10.1074/JBC.M112.355164
A Matsumori, T Yamada, H Suzuki, Y Matoba, S Sasayama, Increased circulating cytokines in patients with myocarditis and cardiomyopathy. Heart. ,vol. 72, pp. 561- 566 ,(1994) , 10.1136/HRT.72.6.561
Shishui Lin, Meiguang Qiu, Jianting Chen, IL-4 Modulates Macrophage Polarization in Ankylosing Spondylitis. Cellular Physiology and Biochemistry. ,vol. 35, pp. 2213- 2222 ,(2015) , 10.1159/000374026
Steven E. Mutsaers, Darrel Whitaker, John M. Papadimitriou, Stimulation of mesothelial cell proliferation by exudate macrophages enhances serosal wound healing in a murine model. American Journal of Pathology. ,vol. 160, pp. 681- 692 ,(2002) , 10.1016/S0002-9440(10)64888-2
Tetsuo Shioi, Akira Matsumori, Shigetake Sasayama, Persistent Expression of Cytokine in the Chronic Stage of Viral Myocarditis in Mice Circulation. ,vol. 94, pp. 2930- 2937 ,(1996) , 10.1161/01.CIR.94.11.2930
Honghong Sun, Shunyou Gong, Ruaidhri J. Carmody, Anja Hilliard, Li Li, Jing Sun, Li Kong, Lingyun Xu, Brendan Hilliard, Shimin Hu, Hao Shen, Xiaolu Yang, Youhai H. Chen, TIPE2, a Negative Regulator of Innate and Adaptive Immunity that Maintains Immune Homeostasis Cell. ,vol. 133, pp. 415- 426 ,(2008) , 10.1016/J.CELL.2008.03.026
Yuji Hiraoka, Chiharu Kishimoto, Hitoshi Takada, Nario Suzaki, Kimiyasu Shiraki, Colony-stimulating factors and coxsackievirus B3 myocarditis in mice: Macrophage colony-stimulating factor suppresses acute myocarditis with increasing interferon-α American Heart Journal. ,vol. 130, pp. 1259- 1264 ,(1995) , 10.1016/0002-8703(95)90152-3