Urinary EpCAM in urothelial bladder cancer patients: characterisation and evaluation of biomarker potential.

摘要: Epithelial cell adhesion molecule is overexpressed in bladder tumours and released from cancer cells vitro. We test the hypotheses that urinary EpCAM could act as a biomarker for primary detection risk stratification. was measured by ELISA urine 607 patients with 53 non-cancer controls. Mann–Whitney tests ROC analyses were used to determine statistical significance discrimination between controls different stages grades of disease. Multivariable modelling Kaplan–Meier prognostic significance. The structure investigated western blotting mass spectrometry. Urinary levels increase stage grade cancer. Alongside stage, elevated an independent indicator poor prognosis hazard ratio 1.76 cancer-specific mortality. soluble form extracellular domain generated cleavage ala243 gly244. Further studies are required define influence other tract malignancies benign urological conditions on EpCAM. shed into tumours. strong survival, may be useful within multi-marker panel disease or stand-alone marker prioritise investigation treatment patients. mechanisms effects worthy further investigation, identify novel therapeutic targets.