N-ras mutations in human cutaneous melanoma from sun-exposed body sites.
作者： L J van 't Veer , B M Burgering , R Versteeg , A J Boot , D J Ruiter
DOI: 10.1128/MCB.9.7.3114
关键词:
摘要: In 7 of 37 patients with cutaneous melanoma, mutations in the N-ras gene were found. The primary tumors these seven exclusively localized on body sites continuously exposed to sunlight. Moreover, ras all at or near dipyrimidine known be targets UV damage. Two biclonal respect mutation. An active role for irradiation induction is suggested.
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