FOXP2 promotes the nuclear translocation of POT1, but FOXP2(R553H), mutation related to speech-language disorder, partially prevents it
作者： Yuko Tanabe , Eriko Fujita , Takashi Momoi
DOI: 10.1016/J.BBRC.2011.06.032
关键词:
摘要: FOXP2 is a forkhead box-containing transcription factor with several recognizable sequence motifs. However, little known about the FOXP2-associated proteins except for C-terminal binding protein (CtBP). In present study, we attempted to isolate yeast two-hybrid system using region, including domain, as bait probe, and identified protection of telomeres 1 (POT1) protein. Immunoprecipitation assay confirmed association POT1. POT1 alone localized in cytoplasm but co-localized domain nuclei. both mutated nuclear localization signals (R553H) forkhead, which associated speech-language disorder, prevented translocation These results suggest that partner As loss function induces cell arrest, impaired developing neuronal cells may be pathogenesis disorder FOXP2(R553H) mutation.
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