Perspectives on complement in xenotransplantation.

摘要: The crucial role of complement and naturally occurring anti-Gal antibodies in hyperacute rejection pig transplants to Old World monkeys, apes humans is well established. This can be prevented by manipulating either system. Although cells, tissues or organs from pigs made transgenic for human regulatory proteins escape rejection, there an increasing evidence a also the subsequent acute vascular delayed xenograft rejection. Furthermore, contributes general manner ischemia-reperfusion injury (IRI), irrespective organ source. Early complement-mediated endothelial cell activation, although not sufficient induce may contribute reduced long-time graft performance. Control fluid-phase activation soluble inhibitors might important adjuvant time harvesting through first post-transplant period. Pharmacologic manipulation field expansion, though still its infancy. optimal cloned close reality, xenotransplantation needs fully elucidated treatment regimen inhibition warranted. story completed but under continuous revision.