Proceedings of the first international summit on intestinal anastomotic leak, Chicago, Illinois, October 4-5, 2012.

摘要: Objective: The first international summit on anastomotic leak was held in Chicago October, 2012 to assess current knowledge the field and develop novel lines of inquiry. following report is a summary proceedings with commentaries future prospects for clinical trials laboratory investigations. Background: Anastomotic leakage remains devastating problem patient, continuing challenge surgeon operating high-risk areas gastrointestinal tract such as esophagus rectum. Despite traditional wisdom that because technique, evidence support this weak-to-non-existent. Outcome data continue demonstrate expert high-volume surgeons working centers experience leaks cannot predict reliably which patients will leak. Methods: A one one-half day small group assembled review practices, opinions, scientific evidence, potential paths forward understand decrease incidence leak. Results: Results survey opinions demonstrated majority participants believe complicated biologic whose pathogenesis ill-defined. opined underreported clinically, it not technique except when there gross inattention it, results from animal models are mostly irrelevant human condition. Conclusions: fresh unbiased examination causes strategies prevention needs be addressed by continuous surgeons, basic scientists, trialists realize real significant reduction its morbidity. Such path discussed.