Msx1 Cooperates with Histone H1b for Inhibition of Transcription and Myogenesis
作者： Hansol Lee , Raymond Habas , Cory Abate-Shen
关键词:
摘要: During embryogenesis, differentiation of skeletal muscle is regulated by transcription factors that include members the Msx homeoprotein family. By investigating Msx1 function in repression myogenic gene expression, we identified a physical interaction between and H1b, specific isoform mouse histone H1. We found H1b bind to key regulatory element MyoD , central regulator differentiation, where they induce repressed chromatin. Moreover, cooperate inhibit cell culture Xenopus animal caps. Our findings define previously unknown for “linker” histones gene-specific transcriptional regulation.
sciencemag.org
harvard.edu
unirioja.es参考文章(23)
Oliver C. Steinbach, Alan P. Wolffe, Ralph A.W. Rupp, Somatic linker histones cause loss of mesodermal competence in Xenopus Nature. ,vol. 389, pp. 395- 399 ,(1997) , 10.1038/38755
H Zhang, G Hu, H Wang, P Sciavolino, N Iler, M M Shen, C Abate-Shen, Heterodimerization of Msx and Dlx homeoproteins results in functional antagonism. Molecular and Cellular Biology. ,vol. 17, pp. 2920- 2932 ,(1997) , 10.1128/MCB.17.5.2920
M. Shani, B.P. Brunk, D.J. Goldhamer, C.P. Emerson, A. Faerman, A. King, Embryonic activation of the myoD gene is regulated by a highly conserved distal control element. Development. ,vol. 121, pp. 637- 649 ,(1995)
Zeng-Feng Wang, Allen M Sirotkin, Gregory M Buchold, Arthur I Skoultchi, William F Marzluff, The mouse histone H1 genes: gene organization and differential regulation. Journal of Molecular Biology. ,vol. 271, pp. 124- 138 ,(1997) , 10.1006/JMBI.1997.1166
Akimitsu Konishi, Shigeomi Shimizu, Junko Hirota, Toshifumi Takao, Yuhong Fan, Yosuke Matsuoka, Lilin Zhang, Yoshihiro Yoneda, Yoshitaka Fujii, Arthur I. Skoultchi, Yoshihide Tsujimoto, Involvement of Histone H1.2 in Apoptosis Induced by DNA Double-Strand Breaks Cell. ,vol. 114, pp. 673- 688 ,(2003) , 10.1016/S0092-8674(03)00719-0
Brian D. Strahl, C. David Allis, The language of covalent histone modifications. Nature. ,vol. 403, pp. 41- 45 ,(2000) , 10.1038/47412
Xuetong Shen, Lanlan Yu, Joyce W. Weir, Martin A. Gorovsky, Linker histories are not essential and affect chromatin condensation in vivo Cell. ,vol. 82, pp. 47- 56 ,(1995) , 10.1016/0092-8674(95)90051-9
Paul Woloshin, Kening Song, Catherine Degnin, Ann McNeill Killary, David J. Goldhamer, David Sassoon, Mathew J. Thayer, MSX1 inhibits MyoD expression in fibroblast × 10T½ cell hybrids Cell. ,vol. 82, pp. 611- 620 ,(1995) , 10.1016/0092-8674(95)90033-0
Ronald W. Lennox, Leonard H. Cohen, The production of tissue-specific histone complements during development. Biochemistry and Cell Biology. ,vol. 66, pp. 636- 649 ,(1988) , 10.1139/O88-073
Jessica A Downs, Effie Kosmidou, Alan Morgan, Stephen P Jackson, Suppression of Homologous Recombination by the Saccharomyces cerevisiae Linker Histone Molecular Cell. ,vol. 11, pp. 1685- 1692 ,(2003) , 10.1016/S1097-2765(03)00197-7