PVF1, a PDGF/VEGF homolog, is sufficient to guide border cells and interacts genetically with Taiman

摘要: The border cells of the Drosophila ovary undergo a well-defined and developmentally regulated cell migration. Two signals have previously been shown to control where and when migrate. steroid hormone ecdysone, acting through its receptor coactivator known as Taiman, contributes regulating timing PVF1, growth factor related platelet-derived growth factor vascular-endothelial growth factor, contributes guiding oocyte. To probe the mechanisms controlling migration further, we performed a screen for genes that exhibit dominant genetic interactions with taiman . We identified 14 genomic regions interact Within one region, Pvf1 gene responsible interaction. Signaling by PVF1 has been proposed guide the their proper target, but ectopic not tested for ability redirect cells. tested PVF1, as well other factors such Gurken, guide new targets. Our results demonstrate expression is sufficient to in some egg chambers factors tested are not. These data suggest guidance migration is robust there likely be additional contribute to long-range these In addition, find that regulate dynamic localization of E-cadherin cells, possibly accounting interaction between two pathways.