Investigation into the Toxicity of Traditional Uyghur Medicine Quercus Infectoria Galls Water Extract

摘要: Objective Quercus infectoria galls (QIG) is being widely used in Traditional Uyghur Medicine. To gather preclinical safety information for the aqueous extract of QIG, a toxicity study was performed. Methods Subject animals were randomized, and devided into exposure control groups. In acute phase, three different doses—5, 7.5, 10 g/kg, respectively—were administered via enema to imprinting region (ICR) mice. An experiment using maximum tolerance dose (MTD) i.e.10 g/kg also performed. Data gathered 14 days, parameters clinical signs, body weight, general behavior, adverse effects mortality. At day 14, major organs subjects examined histologically. Chronic evaluated Wistar rats over 180 consecutive days. The divided groups with doses 0.2 0.8 2 QIG. Furthermore, observations carried out rabbits investigate if there signs irritation. Results In comparison group, acute, chronic mortality not significantly increased group. Conclusion Study result suggests that QIG unlikely have significant trials may proceed safely.