Primary mediastinal large B-cell lymphomas treated with dose-intensified CHOP alone or CHOP combined with radiotherapy.

摘要: We retrospectively reviewed 105 cases of primary mediastinal large B-cell lymphoma (PMLBL). Patients were treated with dose-intensified chemotherapy according to the GELA protocols without planned radiotherapy. Radiotherapy was delivered patients a proven sensitive CHOP who could receive irradiation for localised disease. Seventy-six achieved complete remission (24%) or unconfirmed CR (49%), and 15 (14%), partial remission. intensified induction therapy had better FFP rate than even when radiotherapy restricted responders regimen (p = 0.01). In multivariate analysis overall survival, poor performance status remained associated outcome 0.02 0.02, respectively). might not be necessary in PMLBL Cru is chemotherapy. yield inferior results compared more frequent progression on therapy.