Gliadin Nanoparticles Induce Immune Tolerance to Gliadin in Mouse Models of Celiac Disease.

作者: Tobias L. Freitag , Joseph R. Podojil , Ryan M. Pearson , Frank J. Fokta , Cecilia Sahl

DOI: 10.1053/J.GASTRO.2020.01.045

关键词:

摘要: … of gliadin protein encapsulated in TIMP (referred to as TIMP-GLIA), harboring immunodominant and subdominant gliadin … at inducing gliadin immune tolerance and reducing gliadin-…

参考文章(38)
Sarah L. Hayward, Norma Bautista-Lopez, Kunimasa Suzuki, Alexey Atrazhev, Peter Dickie, John F. Elliott, CD4 T Cells Play Major Effector Role and CD8 T Cells Initiating Role in Spontaneous Autoimmune Myocarditis of HLA-DQ8 Transgenic IAb Knockout Nonobese Diabetic Mice Journal of Immunology. ,vol. 176, pp. 7715- 7725 ,(2006) , 10.4049/JIMMUNOL.176.12.7715
A. I. Lahdenperä, V. Hölttä, T. Ruohtula, H. M. Salo, L. Orivuori, M. Westerholm-Ormio, E. Savilahti, K. Fälth-Magnusson, L. Högberg, J. Ludvigsson, O. Vaarala, Up-regulation of small intestinal interleukin-17 immunity in untreated coeliac disease but not in potential coeliac disease or in type 1 diabetes. Clinical and Experimental Immunology. ,vol. 167, pp. 226- 234 ,(2012) , 10.1111/J.1365-2249.2011.04510.X
Carole Lavigne, Anne-Sophie Guedj, Arnold Kell, Michael Barnes, Sandra Stals, David Gonçalves, Denis Girard, Preparation, characterization, and safety evaluation of poly(lactide-co-glycolide) nanoparticles for protein delivery into macrophages. International Journal of Nanomedicine. ,vol. 10, pp. 5965- 5979 ,(2015) , 10.2147/IJN.S82205
Beata Toth, Eva Garabuczi, Zsolt Sarang, György Vereb, György Vámosi, Daniel Aeschlimann, Bernadett Blasko, Balint Becsi, Ferenc Erdodi, Adam Lacy-Hulbert, Ailiang Zhang, Laura Falasca, Raymond B Birge, Zoltan Balajthy, Gerry Melino, László Fésüs, Zsuzsa Szondy, None, Transglutaminase 2 is needed for the formation of an efficient phagocyte portal in macrophages engulfing apoptotic cells. Journal of Immunology. ,vol. 182, pp. 2084- 2092 ,(2009) , 10.4049/JIMMUNOL.0803444
Daniel R. Getts, Danielle M. Turley, Cassandra E. Smith, Christopher T. Harp, Derrick McCarthy, Emma M. Feeney, Meghann Teague Getts, Aaron J. Martin, Xunrong Luo, Rachael L. Terry, Nicholas J. C. King, Stephen D. Miller, Tolerance Induced by Apoptotic Antigen-Coupled Leukocytes Is Induced by PD-L1+ and IL-10–Producing Splenic Macrophages and Maintained by T Regulatory Cells Journal of Immunology. ,vol. 187, pp. 2405- 2417 ,(2011) , 10.4049/JIMMUNOL.1004175
Daniel R Getts, Aaron J Martin, Derrick P McCarthy, Rachael L Terry, Zoe N Hunter, Woon Teck Yap, Meghann Teague Getts, Michael Pleiss, Xunrong Luo, Nicholas JC King, Lonnie D Shea, Stephen D Miller, Microparticles bearing encephalitogenic peptides induce T-cell tolerance and ameliorate experimental autoimmune encephalomyelitis Nature Biotechnology. ,vol. 30, pp. 1217- 1224 ,(2012) , 10.1038/NBT.2434
Judit Hodrea, Máté Á. Demény, Gyöngyike Majai, Zsolt Sarang, Ilma Rita Korponay-Szabó, László Fésüs, Transglutaminase 2 is expressed and active on the surface of human monocyte-derived dendritic cells and macrophages. Immunology Letters. ,vol. 130, pp. 74- 81 ,(2010) , 10.1016/J.IMLET.2009.12.010
X. Luo, K. L. Pothoven, D. McCarthy, M. DeGutes, A. Martin, D. R. Getts, G. Xia, J. He, X. Zhang, D. B. Kaufman, S. D. Miller, ECDI-fixed allogeneic splenocytes induce donor-specific tolerance for long-term survival of islet transplants via two distinct mechanisms Proceedings of the National Academy of Sciences of the United States of America. ,vol. 105, pp. 14527- 14532 ,(2008) , 10.1073/PNAS.0805204105
Ellen M. Nilsen, Frode L. Jahnsen, Knut E.A. Lundin, Finn–Eirik Johansen, Olav Fausa, Ludvig M. Sollid, Jørgen Jahnsen, Helge Scott, Per Brandtzaeg, Gluten induces an intestinal cytokine response strongly dominated by interferon gamma in patients with celiac disease Gastroenterology. ,vol. 115, pp. 551- 563 ,(1998) , 10.1016/S0016-5085(98)70134-9
Jane Bryant, Kelan A. Hlavaty, Xiaomin Zhang, Woon-Teck Yap, Lei Zhang, Lonnie D. Shea, Xunrong Luo, Nanoparticle delivery of donor antigens for transplant tolerance in allogeneic islet transplantation. Biomaterials. ,vol. 35, pp. 8887- 8894 ,(2014) , 10.1016/J.BIOMATERIALS.2014.06.044