Increased diffusivity in acute multiple sclerosis lesions predicts risk of black hole

摘要: Objective: Diffusion tensor imaging (DTI) quantifies Brownian motion of water within tissue. Inflammation leads to tissue injury, resulting in increased diffusivity and decreased directionality. We hypothesize that DTI can quantify the damage acute multiple sclerosis (MS) white matter lesions predict gadolinium (Gd)-enhancing will persist 12 months later as T1 hypointensities. Methods: A cohort 22 individuals underwent 7 brain MRI scans over 15 months. parameters were temporally quantified regions Gd enhancement. Comparison homologous region hemisphere contralateral Gd-enhancing lesion was also performed standardize individual parameters. Results: After classifying each black hole outcome, radial diffusivity, mean fractional anisotropy, along with their standardized values, significantly altered for persistent holes (PBHs), remained elevated throughout study. a 40% elevation had 5.4-fold (95% confidence interval [CI]: 2.1, 13.8) risk becoming PBH, 70% CI: 51%, 85%) sensitivity 69% 57%, 80%) specificity. model volume length enhancement, associated PBH 5.0 2.6, 9.9). Altered displayed dose relationship duration persistence. Conclusions: Elevated during enhancement development hole, surrogate severe demyelination axonal injury. An active may be indicative more