Gene expression profiling of craniofacial fibrous dysplasia reveals ADAMTS2 overexpression as a potential marker.

摘要: Fibrous dysplasia (FD) as an abnormal bone growth is one of the common fibro-osseous leasions (FOL) in oral and maxillofacial region, however, its etiology still remains unclear. Here, we performed gene expression profiling FD using microarray analysis to explore key molecule events development, develop potential diagnostic markers or therapeutic targets for FD. We found that 1,881 genes exhibited differential with more than two-fold changes compared normal tissues, including 1,200 upregulated 681 downregulated genes. Pathway indicated obviously activated pathways are Ribosome ECM-receptor interaction pathways; “Hepatitis C” “cancer” signaling pathways. further validated ADAMTS2, most differentiated expressed genes, by Immunohistochemistry (IHC) 40 cases. Results showed ADAMTS2 was significantly overexpressed but rarely suggesting could be a biomarker Thus, this study uncovered differentially candidate FD, which provides pilot data understanding pathogenesis, developing novel biomarkers diagnosis targeting