Male circumcision decreases high-risk human papillomavirus viral load in female partners: A randomized trial in Rakai, Uganda

摘要: Male circumcision (MC) reduces high-risk human papillomavirus (HR-HPV) infection in female partners. We evaluated the intensity of HR-HPV viral DNA load HIV-negative, HR-HPV-positive partners circumcised and uncircumcised men. HIV-negative men their were enrolled randomized trials MC Rakai, Uganda. Vaginal swabs tested for genotypes by Roche HPV Linear Array which provides a semi-quantitative measure genotype-specific bands (graded:1-4). assessed effects on comparing high linear array (3-4) to low (1-2) using an intention-to-treat analysis. Prevalence risk ratios (PPR) intervention versus control arm estimated log-binomial regression with robust variance. The trial included 335 women male 340 arm. At enrollment, frequency was similar both study arms. 24 months follow-up, prevalence among detectable HRHPV significantly lower (42.7%) than (55.1%, PRR= 0.78, 95%CI 0.65-0.94, p=0.02), primarily incident infections (PRR=0.66, 95% CI 0.50-0.87, p=0.003), but not persistent (PRR=1.02, 0.83-1.24). Genotypes band more likely persist (adjHR=1.27 1.07-1.50), irrespective partner status. newly infected