Tuning the response of a pH-sensitive membrane switch

摘要: We have shown that the hydrophobic polyelectrolyte poly-(2-ethylacrylic acid) (PEAA, 1) causes destabilization of lipid bilayer membranes at pH 6.55 or lower and this pH-sensitive [compound 1] response can be used to trigger release hydrophilic compounds entrapped in liposomes. Responsive membrane systems are finding increasingly important applications drug delivery, signal amplification biochemical assay, molecular recognition.