Study of Binding Properties Between Two New Ibuprofen and Naproxen Based Acyl Hydrazone Derivatives and Trypsin
作者： Elmas Gökoğlu , Esra Yılmaz , Esra Gökoğlu , Ayşe Uzgören Baran
DOI: 10.1007/S10895-015-1690-2
关键词:
摘要: Two acyl hydrazone derivatives, AHI and AHN,made from ibuprofen naproxen-derived hydrazides, were prepared studied of binding properties with serine protease trypsin by UV-vis absorption fluorescence quenching at pH 7.4. The results suggest that both hydrazones can interact strongly there are the formation trypsin-hydrazone complexes. Stern-Volmer constants, constants,binding sites corresponding thermodynamic parameters ΔH°, ΔS° ΔG° calculated different temperatures.The effect common metal ions on constants was also discussed. modes be explained basis hydrogen bonds van der Waals forces. distance(r) ~3 nm between donor (trypsin) acceptors (AHI AHN) obtained according to Forster's non-radiative energy transfer theory. Moreover, LOD LOQ in presence trypsin.
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