Anginex-conjugated liposomes for targeting of angiogenic endothelial cells.

摘要: Identification of a tumor angiogenesis specific ligand would allow targeting vasculature. Lipidic vehicles can be used to deliver therapeutic agents for treatment disease or contrast molecular imaging. A delivery such formulations angiogenic sites, thereby reducing side effects and gaining efficiency. Anginex, synthetic 33-mer angiostatic peptide, has been described home angiogenically activated endothelium, suggesting an ideal candidate as ligand. To investigate this application anginex, fluorescently labeled paramagnetic liposomes were conjugated with anginex. Using phase fluorescence microscopy well magnetic resonance imaging (MRI), we demonstrate that anginex-conjugated bind specifically endothelial cells, agent angiogenesis-dependent disease.