Vaccine development. On relating immunology to the Third World: some studies on leprosy.

摘要: The potential of maternally derived cellular factors to mediate immunity Trichinella spiralis in neonates during lactation was investigated this study. Female FI rats, infected with T. spiralis, were able transfer their suckling offspring, evidenced by a significant reduction the intestinal parasite burdens neonates. When challenged between 2 and 3 weeks age 200 larvae, pups on immune mothers harboured 28% 26% (at 8 days post-challenge) worm numbers present control naive mothers. Cross-fostering experiments which born but nursed showed immunity, demonstrated that passage occurred through milk. role cell-mediated analysed using T cells purified from MLN syngeneic donor rats spiralis. x 10(6) sensitized adoptively transferred into lactating recipients, it led passive immunization (26% 13% values retained at post-challenge), while maternal injection primed an irrelevant antigen (KLH) had no effect neonatal immunity. Neonates fed per-orally lymphocytes early prior challenge also rendered (34% 44% post-challenge). A single dose spiralis-primed given sufficient elicit response them age. These results support hypothesis mediated antigen-specific milk can provide functional protection neonate against pathogen.