Amyloidosis and female protein in the Syrian hamster. Concurrent regulation by sex hormones.

摘要: Previous results have shown that when compared to male Syrian hamsters, female hamsters a distinct predisposition acquire amyloidosis either normally with aging or experimentally sodium caseinate diethylstilbestrol (DES) treatments. In the present study, we tested influence of testosterone on expression amyloid determine if this hormone was solely responsible for sex-limited hamster. Males deprived by castration acquired at an unusually young age, age onset similar in hamsters. Also, amyloidogenic effect DES inhibited concomitant injections testosterone, indicating estrogens induce inhibiting synthesis. When administered and extended life span gender. Of two components amyloid, major component Amyloid A-derived fibril minor constituent, P component, only is under sex control hamster; inhibits hepatic synthesis homologue (called protein), which expressed 100-200-fold greater vs. general, serum level protein various experimental conditions correlated presence indicated hamster primary importance deposition amyloid.