The NKG2D receptor: sensing stressed cells
作者： Carlos López-Larrea , Beatriz Suárez-Alvarez , Alejandro López-Soto , Antonio López-Vázquez , Segundo Gonzalez
DOI: 10.1016/J.MOLMED.2008.02.004
关键词:
摘要: The activating killer cell lectin-like receptor NKG2D plays a key role in the natural (NK) cell-mediated lysis of tumours and infected cells. Unlike other receptors, ligands recognised by are 'induced-self' on stressed This system requires precise regulation because inappropriate expression might compromise NK activation. For therapeutic purposes it is essential to understand mechanisms that regulate function system. review focuses importance signalling pathways involved its ligand arming immune response against or tumour cells for identification new molecular targets strategies.
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