USP15 stabilizes TGF-β receptor I and promotes oncogenesis through the activation of TGF-β signaling in glioblastoma

作者: Pieter J A Eichhorn , Laura Rodón , Alba Gonzàlez-Juncà , Annette Dirac , Magüi Gili

DOI: 10.1038/NM.2619

关键词:

摘要: … with GBM having more than 2.5 copies of USP15 had a shorter life expectancy than those with GBM and two or less copies of the gene. Hence, the amplification of USP15 in GBM …

参考文章(37)
Jeremy N Rich, The role of transforming growth factor-beta in primary brain tumors Frontiers in Bioscience. ,vol. 8, pp. e245- 260 ,(2003) , 10.2741/992
A.J. van der Eb, F.L. Graham, [75] Assay of transforming activity of tumor virus DNA Nucleic Acids Part I. ,vol. 65, pp. 826- 839 ,(1980) , 10.1016/S0076-6879(80)65077-0
Eric C. Holland, Gliomagenesis: genetic alterations and mouse models Nature Reviews Genetics. ,vol. 2, pp. 120- 129 ,(2001) , 10.1038/35052535
Haitao Zhu, Peter Kavsak, Shirin Abdollah, Jeffrey L Wrana, Gerald H Thomsen, None, A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation. Nature. ,vol. 400, pp. 687- 693 ,(1999) , 10.1038/23293
Atsuhito Nakao, Mozhgan Afrakhte, Anita Morn, Takuya Nakayama, Jan L. Christian, Rainer Heuchel, Susumu Itoh, Masahiro Kawabata, Nils-Erik Heldin, Carl-Henrik Heldin, Peter ten Dijke, Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling Nature. ,vol. 389, pp. 631- 635 ,(1997) , 10.1038/39369
Y. Zhang, C. Chang, D. J. Gehling, A. Hemmati-Brivanlou, R. Derynck, Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 98, pp. 974- 979 ,(2001) , 10.1073/PNAS.98.3.974
Tetsu Kamitani, Katsumi Kito, Hung P. Nguyen, Edward T. H. Yeh, Characterization of NEDD8, a Developmentally Down-regulated Ubiquitin-like Protein Journal of Biological Chemistry. ,vol. 272, pp. 28557- 28562 ,(1997) , 10.1074/JBC.272.45.28557
Abiodun A Ogunjimi, Douglas J Briant, Nadia Pece-Barbara, Christine Le Roy, Gianni M Di Guglielmo, Peter Kavsak, Richele K Rasmussen, Bruce T Seet, Frank Sicheri, Jeffrey L Wrana, None, Regulation of Smurf2 Ubiquitin Ligase Activity by Anchoring the E2 to the HECT Domain Molecular Cell. ,vol. 19, pp. 297- 308 ,(2005) , 10.1016/J.MOLCEL.2005.06.028
Julien Moretti, Patricia Chastagner, Stefano Gastaldello, Sara F. Heuss, Annette M. Dirac, René Bernards, Maria G. Masucci, Alain Israël, Christel Brou, The Translation Initiation Factor 3f (eIF3f) Exhibits a Deubiquitinase Activity Regulating Notch Activation PLoS Biology. ,vol. 8, pp. e1000545- ,(2010) , 10.1371/JOURNAL.PBIO.1000545