Prognostic significance of p21WAF1/CIP1, p27Kip1, p53 and E-cadherin expression in gastric cancer.
作者： A. Gamboa-Dominguez , S. Seidl , E. Reyes-Gutierrez , C. Hermannstadter , L. Quintanilla-Martinez
关键词:
摘要: Background: Gastric carcinoma is characterized by numerous genetic and epigenetic alterations that influence cell cycle progression, apoptosis, DNA repair. These include down-regulation of the cyclin-dependent kinase (CDK) inhibitors p21WAF1/CIP1 p27Kip1, mutations tumor suppressor protein p53 adhesion molecule E-cadherin. Combined evaluation prognostic significance these has not been reported in Mexican Mestizo patients so far. Aims: The aim study was a combined p21WAF1/CIP1, E-cadherin expression, including mutant variants with deletion exon 8 (del 8) or 9 9), gastric cancer from patients. Methods: Immunohistochemistry for above-mentioned markers mutation-specific antibodies carried out 69 carcinomas expression levels were correlated histotype, stage, prognosis. Results: Expression alone combination p27Kip1 absence associated favourable Staining del found exclusively negative positive suggesting regulatory function intact. Conclusion: regulators should be performed. Even though have prognosis, it may on prognosis if they acquire addition which shown previously to poor survival.
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