Genetic therapies for cardiovascular diseases
作者： Luis G. Melo , Alok S. Pachori , Massimiliano Gnecchi , Victor J. Dzau
DOI: 10.1016/J.MOLMED.2005.03.008
关键词:
摘要: Recent advances in understanding the molecular and cellular basis of cardiovascular diseases, together with availability tools for genetic manipulation system, offer possibilities new treatments. Gene therapies have demonstrated potential usefulness treating complex such as hypertension, atherosclerosis myocardial ischemia, various animal models. Some these experimental are now undergoing clinical evaluation patients disease. However, successful transition into mainstream practice awaits further improvements to vector platforms delivery documentation feasibility, safety efficacy through multi-center randomized trials.
elsevier.com
sci-hub.se 参考文章(102)
Michael J. Katovich, Craig H. Gelband, Phyllis Reaves, Hong-Wei Wang, Mohan K. Raizada, Reversal of hypertension by angiotensin II type 1 receptor antisense gene therapy in the adult SHR American Journal of Physiology-heart and Circulatory Physiology. ,vol. 277, ,(1999) , 10.1152/AJPHEART.1999.277.3.H1260
Bruce D. Klugherz, Cunxian Song, Suzanne DeFelice, Xiumin Cui, Zhiban Lu, Jeanne Connolly, J. Travis Hinson, Robert L. Wilensky, Robert J. Levy, Gene Delivery to Pig Coronary Arteries from Stents Carrying Antibody-Tethered Adenovirus Human Gene Therapy. ,vol. 13, pp. 443- 454 ,(2002) , 10.1089/10430340252792576
RS Agrawal, S Muangman, MD Layne, L Melo, MA Perrella, RT Lee, L Zhang, M Lopez-Ilasaca, VJ Dzau, None, Pre-emptive gene therapy using recombinant adeno-associated virus delivery of extracellular superoxide dismutase protects heart against ischemic reperfusion injury, improves ventricular function and prolongs survival Gene Therapy. ,vol. 11, pp. 962- 969 ,(2004) , 10.1038/SJ.GT.3302250
Gregory J. Hannon, RNA interference : RNA Nature. ,vol. 418, pp. 244- 251 ,(2002)
A.R. Lorimer, William Stewart Williams, Cardiovascular Disease ,(1985)
R.Morton Bolman, Editorial: Intracoronary adenovirus-mediated transfer of immunosuppressive cytokine genes prolongs allograft survival The Journal of Thoracic and Cardiovascular Surgery. ,vol. 115, pp. 819- 821 ,(1998) , 10.1016/S0022-5223(98)70361-7
Edith Tzeng, Larry L. Shears, Paul D. Robbins, Bruce R. Pitt, David A. Geller, Simon C. Watkins, Richard L. Simmons, Timothy R. Billiar, Vascular Gene Transfer of the Human Inducible Nitric Oxide Synthase: Characterization of Activity and Effects on Myointimal Hyperplasia Molecular Medicine. ,vol. 2, pp. 211- 225 ,(1996) , 10.1007/BF03401618
C Vijayasarathy, R M Zwacka, T J Gardner, Y J Woo, J F Englehardt, H L Sweeney, J C Zhang, Recombinant adenovirus-mediated cardiac gene transfer of superoxide dismutase and catalase attenuates postischemic contractile dysfunction. Circulation. ,vol. 98, ,(1998)
J. Kevin Donahue, Alan W. Heldman, Heather Fraser, Amy D. McDonald, Julie M. Miller, Jeffrey J. Rade, Thomas Eschenhagen, Eduardo Marbán, Focal modification of electrical conduction in the heart by viral gene transfer Nature Medicine. ,vol. 6, pp. 1395- 1398 ,(2000) , 10.1038/82214
Jeffrey M. Isner, Myocardial gene therapy Nature. ,vol. 415, pp. 234- 239 ,(2002) , 10.1038/415234A