Novel anticancer drug protocols

摘要: Part I. Introduction Overview of Novel Anticancer Drug Targets John K. Buolamwini and Haregewein Assefa II. Kinase Inhibitor Discovery Protocols Biomarker Assays for Phosphorylated MAP Kinase: Their Utility Measurement MEK Inhibition Judith S. Sebolt-Leopold, Keri Van Becelaere, Kenneth Hook, Roman Herrera Cyclin-Dependent Inhibitors Adrian M. Senderowicz Tyler Lahusen Identifying ATM ATR Activities Jann N. Sarkaria III. Angiogenesis Metastasis The Rat Aortic Ring Assay In Vitro Study Ronald Go Whyte G. Owen Real Time Vivo Quantitation Tumor Gregory Frost Per Borgstrom Use Tumor-Activated Hepatic Stellate Cell as a Target the Preclinical Testing Anti-Angiogenic Drugs Against Development Elvira Olaso Fernando Vidal-Vanaclocha Motility, Adhesion, Homing, Migration in Studies Tyrosine Kinases Martin Sattler, Elizabeth Quackenbush, Ravi Salgia Inflammatory Response Sinusoidal Endothelium Screening Chemopreventive Lorea Mendoza Binding Selectins Jianing Zhang Michiko Fukuda Determination Peak Serum Levels Immune to Humanized Anti-Ganglioside Antibody-Interleukin-2 Immunocytokine Jacquelyn A. Hank, Jean E. Surfus, Jacek Gan, Amy Ostendorf, Stephen D. Gillies, Paul Sondel IV. Immunohistochemical Clinical Setting EGFR-Tyrosine Samples Shazli Malik, Roble Bedolla, Manuel Hidalgo, Michael Brattain, Jeffrey I.Kreisberg Farnesyltransferase Patient Alex Adjei V. Protein Chaperoning/Degradation HSP90 Wynne Aherne, Alison Maloney, Chris Prodromou, Rowlands, Anthea Hardcastle, Katherine Boxall, Clarke, Walton, Laurence Pearl, Workman Proteasome Peter J. Elliott, Teresa Soucy, Christine Pien, Julian Adams, Eric Lightcap VI. Protein-Protein Protein-DNA Interactions Mammalian Two-Hybrid Detection Coactivator-Nuclear Receptor Curtis Tyree Kay Klausing Preparation DNA-Protein Complexes Suitable Spectroscopic Analysis Nouri Neamati, Manisha Murthy, Yun-Xing Wang VII. Antisense Oligonucleotide MDM2 Oncogene Expression Ruiwen Hui VIII. Genomics Pharmacogenetic Clinically Relevant Genetic Polymorphisms Rose, Sharon Marsh, Margaret-Mary Ameyaw, Howard L. McLeod Gene Microarrays Christopher P. Kolbert, William R. Taylor, Kelly Krajnik, Dennis O'Kane Methods Isolation Circulating DNA Plasma Tomoya Kawaguchi, Will Holland, H. Gumerlock IX. Lifespan/Longevity Early Sea Urchin Embryos David Nishioka, Vanessa Marcell, Meghan Cunningham, Merium Khan, Daniel Von Hoff, Elzbieta Izbicka X. Imaging PET Drugs: A Faster Route Drug/Target Evaluations Anna Fredriksson Stone-Elander XI. Miscellaneous Synergy